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KMID : 1024520220310010023
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Journal of the Environmental Sciences
2022 Volume.31 No. 1 p.23 ~ p.31
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Dioscorea batatas Decne Glycoprotein Prevents Ecotoxicological Effects of Bisphenol A in Gastrointestinal Epithelial Cells and Improves Fecal Malodor and Feed Efficiency in Mice
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Kim Do-Wan
Park Moon-Ki
Kim Tae-Hoon
Lee Sei-Jung
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Abstract
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As a herbal supplement, Dioscorea batatas Decne (DBD) presents potent antioxidant activity and diverse health benefits. In the present study, functions of a 30 kDa glycoprotein isolated from DBD (hereafter, DBD glycoprotein) in the regulation of feed efficiency and fecal malodor in mice were explored. DBD glycoprotein produced protective effect against cytotoxicity induced by the ecotoxicological endocrine-disrupting substance bisphenol A in gastrointestinal epithelial HT-29 cells. To investigate its potential roles in the regulation of feed efficiency and fecal malodor, mice were administered an oral injection of DBD glycoprotein for 2 weeks. Compared with the control values, the weight of internal organs (liver, heart, kidney, and spleen) and levels of glutamate pyruvate transaminase, glutamate oxaloacetate transaminase, and lactic dehydrogenase were not significantly changed during DBD glycoprotein administration for 2 weeks. Interestingly, DBD glycoprotein improved feed efficiency and reduced hydrogen sulfide concentration without altering the ammonia level in mouse feces. Collectively, these results indicate that DBD glycoprotein is a functional agent that exerts gastrointestinal protective effects against ecotoxicological substances, improves feed efficiency, and reduces fecal malodor.
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KEYWORD
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Dioscorea batatas Decne, Ecotoxicological substance, Feed efficiency, Fecal malodor, Glycoprotein
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